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1981 AJP Limbitrol
1981 AJP Limbitrol
New light from a trusted source. Since the turn of the century, Mead johnson has earned the trust of the medical community to produce quality medications in a variety of therapeutic categories. Now, mead Johnson research efforts in psychopharmacotherapy have brough to light newmedications for depressed and anxious patients. Venturing into promising new areas of therapy is a commitment at Mead johnson. Whether producing antibiotic, anticancer, cardiovascular or psychotropic medications, we will apply out pharmaceutical expertise in new and challenging ways for the benefit of generations to come. Mead Johnson, pharmaceutical division. Research in progress points to the role of specific CNS binding sites for the bensodiazepines- often considered the most effective anxiolytic agents. Although the clinical effectiveness of the benzodiazepines is widely accepted by the medical profession, their mechanism of action is as yet unknown. Inability to define a neurophysiological or biochemical basis of anxiety has hindered the search. Current research has, however, identified specific benzodiazepine binding sites in the CNS. Various characteristics of these sites sugest that they may represent the actual sites of action of these agents. Specific tenacity of benzodiazepines to CNS binding sites. In equilibrium bindind studies on rat and human brain tissue, benzodiazepines demonstrate a high affinity for specific sites found primarily in the synaptic membrane fraction. Of the compounds tested, only benzodiazepines compete for these binding sites. Furthermore, each benzodiazepine displays a characteristic degree of affinity which closely parallels its clinical and pharmacological potency. A significant correlation has also been found between the binding affinity of a particular benxodiazepine and its anxiolytic, anticonvulsant and muscle relaxant effects in certain animal tests. Although these in vitro animal and human tissue studies do not necessarily suggest a clinical significance, further investigation of specific benzodiazepine binding sites may provide insight into the mechanism of action of these clinicaly effective anxiolytic agents. While in vitro studies cannot be interpreted to have clinical significance, these represent an attempts to explain the limbitrom clinical affiity in the treatment of moderate to severe depression and anxiety. And to the role od tricyclic antidepressants in blocking the presynaptic reuptake of neurotransmiters- believed important in the treatment of depression. The amine hypothesis, which holds that depression is associated with a deficiency of functional neurotransmitter at the synapse, is currently the most viable theory of depression. It is supported by studies on the pharmacological action of various clinically effective antidepressants. The tricyclics, for instance, have been shwon to block reuptake by the presynaptic terminals, permitting greater availabnility and prolonged action of neurotransmitters at receptor sites. This may compensate for the relative deficit of functional neurotransmitters found in depression. Selective blockade of reuptake. The amine hypothesis has been elaborated to allow for identification of subtypes of depression based on specific neurotransmitter deficiencies. It has been proposed that measurement of the metaboloite 3-methoxy-4-hydroxy-phenylglycol (MHPG) is urine may permit such a differentiation: low MHPG levels indicating a defecit of norepinephrine, and a normal or high MHPG suggesting a deficit of another neurotransmitter, probably serotonin. Current studies indicate that certain tricyclics may be more efficent in blocking norepinephrine reuptake, while others nore selectively blockade serotonin. Further investigation may lead to eventual selection of subtype= specific antidepressants on the basis of biochemical tests. Limbitrol. Dual action specific for dual symptomatology. Limbitrol contains both a benzodiazepine- specific for the symptoms of anxiety, and amitriptyline- specific for depressive symptoms. It therefore provides the agents most appropriate to relieve both symptom syndromes in the nonpsychotic patient with mixed anxiety and depression. What better rationale for prescribing limbitrol for patients who need pharmacological intervention in support of their psychotherapy. Your guide to patient management…when you decide medication is needed. How to initiate and maintain therapy. How to make each patient an informed patient, benzodiazepine and amitriptyline, Mead Johnson/ Roche, artists rendering of synapses and brain in blue and red to mimic microscopy and neural imaging. framed like scientific article, many citations. Offers instructions of how to practice, not just pharmaceutical information. Seems to address fear of physician losing control to medication by saying "when you decide.."
1981 AJP Lithobid
1981 AJP Lithobid
now from CIBA, Slow release Lithobid ™lithium carbonate 300-mg tablets. The stabilizer. Helps defuse the manic phase of depression by maintaining smoother lithium blood levels. Slow-release Lithobid lithium carbonate 300-mg tablets. Slow absorption, enables simple, practical twice-daily dosing., lithium carbonate, CIBA, darkened patient profile full of fireworks, opposite page is full black with fireworks. Next page shows graph of plasma lithium.
1981 AJP Loxitane
1981 AJP Loxitane
Lederle 26mg. If you haven't prescribed this capsule, you haven't experiences the 48-hour loxitane Loxapine Succinate effect… Rapid action. Loxitane Loxapine succinate. For the difference that begins with rapid action, Loxapine Succinate, Lederle, large green capsule pill. main ad doesn't give indication.
1981 AJP Loxitane
1981 AJP Loxitane
Lederle, the name to start with… and stay with. Loxitane 1M, Loxapine hydrochloride intramuscular. Loxitane Capsules, loxapine succinate, loxapine hydrochloride intramuscular, loxapine succinate, Lederle, half page shows physician's hands extracting liquid from bottle labeled Loxitane 1M, other half shows loxitane capsule.
1981 AJP Mellaril
1981 AJP Mellaril
maintainability in the outpatient… a demonstrated ability to help maintain remission of psychotic symptoms. Mellaril (thioridazine). Although extrapyramidal effects are characteristic of antipsychotic agents in general, with Mellaril (thioridazine) extrapyrimidal stimulation is minimal. Adding an antiparkinsonism agent- which can cause its own side effects- can usually be avoided. Mellaril (thioridazine) is contraindicated in patients with hypertensive or hypotensive heart disease of extreme degree. Maintainability in the outpatient.. A demonstrated ability to help maintain remission of psychotic symptoms, thioridazine, sandoz, young woman in dress carrying grocery bag, criticizes side effects of other drugs
1981 AJP Mellaril
1981 AJP Mellaril
The specificity of Mellaril (thioridazine). Active in the limbic system where psychotic symptoms arise… less active where neurotoxic effects occur. Striatal system- minimal extrapyramidal stimulation. Hypothalamus- little effect on temperature-control mechanisms. Hippocampus- minimal effect on seizure threshold. Emetic center- minimal antiemetic activity. Although extrapyramidal effects are characteristic of antipsychotic agents in general, with Mellaril (thioridazine) extrapyramidal stimulation is minimal. Adding an antiparkinsonism agent- which can cause its own side effects- can usually be avoided. Neuroleptic drugs elevate prolactin levels; the elevation persists during chronic administration., thioridazine, sandoz, purple 2D profile of head with schematic brain inside, arrows pointing to different parts with text about effect of drug
1981 AJP Norpramin
1981 AJP Norpramin
When antidepressant therapy keeps your patient in the spiral of non-response. consider changing to a tricyclic that blocks re-uptake of a different neurotransmitter. Norpramin (desipramine hydrochloride tablets NF) Helps the patient better remain calm but active. Begins to improve sleep patterns within one week in some patients. As the depression is relieved, difficulty in falling asleep, restlessness, and early morning awakening diminish. Norpramin does not usually inhibit normal activity, although patietns should be cautioned against driving or operating machinery is drowsiness occurs (see warnings, precautions, and adverse reactions in brief summary overleaf). Less anticholinergic activity. Studies of animal tissues and normal human subjects have shown that desipramine has less anticholinergic activity than amitriptyline or doxepin. The single-bond side chain of desipramine may be associated with less anticholinergic activity than is the double-bond side chain of amitriptyline of doxepin. This may mean less dry mouth, less blurred vision, less urinary retention. Potential blocker of norepinephrine re-uptake. Current evidence suggests depression results from inadequate levels of norepinephrine or serotonin here, at the synaptic cleft. If your patient is unresponsive with treatment of one tricyclic, consider switching to a tricyclic that blocks the re-uptake of a different neurotransmitter. Potent blocker of norepinephrine re-uptake. With improved sleep patterns beginning within one week in some patients. With less anticholinergic activity than amitriptyline or doxepin, as shown in studies of animal tissues and normal human subjects, desipramine hydrochloride tablets NF, Merrel, woman in red walking up endless staircase optical illusion in front of electron microscoph image of neurons and synapses. On opposite page, micrograph and cartoon illustrations of synaptic cleft. criticizes other drugs, evokes fear that MD is currently doing the wrong thing by prescribing other drug
1981 AJP Norpramin
1981 AJP Norpramin
when depression disrupts the day… for the depressed patient who must remain active during the day. Helps the patient remain calm but active. In addition begins to improve sleep patterns within one week in some patients. As the depression is relieved, difficulty in falling asleep, restlessness, and early morning awakening diminish. Less anticholinergic activity, studies in the laboratory and in normal human subjects have shown that desipramine has less anticholinergic activity than amitriptyline or doxepin. This may mean: less dry mouth, less blurred vision, less urinary retention. Potent blocker of norepinephrine re-uptake. Current evidence suggests depression results from inadequate levels of norepinephrine or serotonin here, at the synaptic cleft. If your patient is unresponsive to treatment with one tricyclic, consider switching to a tricyclic that clocks the re-uptake of a different neurotransmitter. Norpramin offers improved sleep patters beginning within one week in some patients. Norpramin provides less anticholinergic activity than amitriptyline or doxepin, as shown in laboratory studies and studies in normal human subjects. Norpramin is a potent blocker of norepinephrine re-uptake, desipramine hydrochloride tablets NF, Merrell, man in suit crying in front of accounting machine, in front of image of neurons and synapses. Opposite page shows enlarged synapse, and diagram of synapse. also about maintaining ability to work!
1981 AJP Norpramin
1981 AJP Norpramin
when the path to therapeutic success is beset by certain problems… start antidepressant therapy with norpramin (desipramine hydrochloride tablets NF) to east the patient's path. Helps relieve the sleep disturbances that often accompany depression. Improvement in sleep patterns may begin within one week in some patients. As the depression is relieves, difficulty in falling asleep, restlessness, and early morning awakening diminish. The patient is helped to remain calm yet active, although the physician should caution the patient about driving or operating heavy machinery if drowsiness occurs. Less anticholinergic activity. Studies of animal tissues and normal human subjects have shown that desipramine has less anticholinergic activity than amitriptyline f doxepin. The single bond side chain of desipramine may be associated with less anticholinergic activity than is the double bond side chain of amitriptyline or doxepin. This may mean less dry mouth, less blurred vision, less urinary retention, less constipation. Potent blocker of norepinephrine re-uptake. Current evidence suggests depression results from inadequate levels of norepinephrine or serotonin here, at the synaptic cleft. If your patient is unresponsive to treatment with one tricyclic, consider switching to a tricyclic that blocks the re-uptake of a different neurotransmitter. Electron micrograph of human synaptic cleft, postulated site of tricyclic antidepressant activity, desipramine hydrchloride, Merrell, man jumping back in surprise amidst electron micrograph image of neurons (I think). Opposite page shows electron microscopy synapse and schematic synapse.
1981 AJP Prolixin
1981 AJP Prolixin
Because your schizophrenic patients are not all from the same mold… there is a form of prolixin (fluphenazine) to suit virtually every clinical need. Some may be eager participants in their therapy. These patients, of course, are usually the easiest to treat. Since they can generally be relied on to take oral medication regularly, you can prescribe prolixin tablets (fluphenazine hydrochloride tablets USP) with confidence. Some may deny their illness- ideal for these patients is long-acting prolixin decanoate (fluphenazine decanoate injection) with a single injection given as infrequently as once a month, they will not have to be reminded every day of the illness they reject so strongly. Some may absorb oral medication poorly- here again, prolixin decanoate can be highly useful be obviating the occasionally encountered problem of peer absorption of oral neuroleptics. Some may be simply unreliable- for unreliably inpatients who sometimes "check" or "pouch" tablets and capsules, Prolixin elixir (fluphenazine hydrochloride elixir USP) can help immeasurably. Unreliable outpatients can best benefit from periodic injections of prolixin decanoate. Some are overtly paranoid- and the paranois often extends to the very medication that is intended to help. Here again, prolixin decanoate provides an assured delivery mechanism. Lengthy interval between doses is also a plus for such patients. Some are acutely ill and agitates- short acting prolixin injection (fluphenazine Hydrochloride injection USP) offers a method of treating these patients immediately with relatively rapid results. Prolixin Fluphenazine: specific for schizophrenia- specifically for the differences among schizophrenics., fluphenazine, Squibb, plaster cast molds of 6 different faces. Face on far left half in mold still. Pill bottles and injection materials at bottom right. a lot about unwilling patients.
1981 AJP Surmontil
1981 AJP Surmontil
Open the way to antidepressant action. In agitated patients, surmontil (trimipramine maleate) relieves agitation and insomnia in just days. Rapid relief of agitation and/or insomnia… often in days. The anxiety survey inventory showed some depressed patients experienced significant (p<.01) relief from insomnia within days. Agitated/depressed patients may also experience symptomatic relief as rapidly. Unaltered REM patterns may allow for a more natural sleep. Unlike nearly all other tricyclics, surmontil has no effect upon REM sleep and does not cause significant change in EEG patterns during normal sleep. Dependable tricyclic efficacy. In separate clinical trials comparing surmontil to either amitriptyline of imipramine, researchers found no significant difference in terms of antidepressive efficacy among the three tricyclics. Well-established record of safety. Surmontil has consistently demonstrated a low incidence of adverse effects. And most patients tolerate it without difficulty in diagnoses of up to 300 mg/day. Minimal effect on normal cardiac function. The effect of surmontil upon normal cardiac function is minimal. Significant adverse reactions such as arrhythmias are infrequent. Rapid anxiolytic action in only days, without a benzodiazepine or a phenothiazine. Anxious depressives showed significant improvement (p,.05) in less than one week in terms of anxiousness as measured by the Hamilton Psychiatric Rating Scale of Depression. Nighttime dosage regimen effective after initial titration. Clinical trials have demonstrated that patients receiving a 150mg nighttime dose after a one-week titration period continued to show significant improvement over baseline, in terms of symptoms measures by the Hamilton depression/anxiety inventory, trimipramine maleate, Ives laboratories, woman peaking through blinds.
1981 AJP Thorazine
1981 AJP Thorazine
Different forms for different folks. Thorazine, brand of chlorpromazine, chlorpromazine, SK&F, variety of different drug administering tools. All look empty or full of clear liquid, very clean and sterile looking.

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