| Note |
When antidepressant therapy keeps your patient in the spiral of non-response. consider changing to a tricyclic that blocks re-uptake of a different neurotransmitter. Norpramin (desipramine hydrochloride tablets NF) Helps the patient better remain calm but active. Begins to improve sleep patterns within one week in some patients. As the depression is relieved, difficulty in falling asleep, restlessness, and early morning awakening diminish. Norpramin does not usually inhibit normal activity, although patietns should be cautioned against driving or operating machinery is drowsiness occurs (see warnings, precautions, and adverse reactions in brief summary overleaf). Less anticholinergic activity. Studies of animal tissues and normal human subjects have shown that desipramine has less anticholinergic activity than amitriptyline or doxepin. The single-bond side chain of desipramine may be associated with less anticholinergic activity than is the double-bond side chain of amitriptyline of doxepin. This may mean less dry mouth, less blurred vision, less urinary retention. Potential blocker of norepinephrine re-uptake. Current evidence suggests depression results from inadequate levels of norepinephrine or serotonin here, at the synaptic cleft. If your patient is unresponsive with treatment of one tricyclic, consider switching to a tricyclic that blocks the re-uptake of a different neurotransmitter. Potent blocker of norepinephrine re-uptake. With improved sleep patterns beginning within one week in some patients. With less anticholinergic activity than amitriptyline or doxepin, as shown in studies of animal tissues and normal human subjects |
