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1981 AJP restoril
1981 AJP restoril
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Metadata (MODS) |
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| Titles | 1981 AJP restoril |
| Related Item | |
| Genre | medicine |
| Identifier | 1981apr_jun |
| Note | now from sandoz… a step closer to the ideal hypnotic. New restoril (temazepam) hypnotic action… with minimal accumulation. Introducing the first new benzodiazepine for sleep… in a decade. New restoril (temazepam) has the shortest half life of any current hypnotic benzodiadepine. It will provide hypnotic action with minimal drug accumulation. Most patients awaken from a full night's sleep alert and refreshed. Also Restoril affords sleep right from the first night for patients with insomnia, eg. Outpatients, hospitalized or convalescent/nursing home patients. Restoril (temazepam) has been tested and proved effective not only in sleep lens but in the patients' bedrooms- the environment where the problem exists. A short half life.. And "ideal" half-life. A short half life: restoril (temazepam) has a mean half-life of 10 hours, the mean half life of flurazepam is 64 hours. The shorter half life permits clearance of most medication prior to the next dose. The half-life of restoril (temazepam) parappels normal sleep time thereby reducing the frequency of middle of the night and early morning awakenings. Minimal to no accumulation. Restoril (temazepam) shows minimal to no accumulation in the body. The activity is essentially limited to the ngith of ingestion… the effect is not additive. This rapid elimination and lack of accumulation virtually eliminates residual hangover effects. Most patients awaken from a full night's sleep feeling alert and refreshed. REM sleep remains virtually unchanged. Works one night at a time… from the first knight. Highly effective in 21 double blind, placebo-controlled studies involving 1221 adult patients (508 of whom received restoril capsules), restoril (temazepam) proved to be an effective sleep agent. The following advantages were noted: therapeutically effective on the first night of therapy. Significantly reduced number of nocturnal awakenings. Effective total sleep time of 7 to 8 hours. Significant improvement in general quality of sleep. Residual redication effect essentially absent. REM sleep remains essentially unchanged. No tolerance reported to date after approximately one month of use (26 patients). Patients receiving Restoril (temazepam) should be cautioned about possible combined effects with alcohol and other CNS depressants, and about operating machinery or driving a vehicle after ingesting the drug. An alert awakening… and an alert patient. Because of the short half life of restoril, there is a minimal accumulation of drug in the body, leaving the patient essentially free of drug effect and showing little or no impairment of behaviour in the morning. In placebo-controlled studies, patients receiving Restoril capsules reported being at least as awake in the morning and as alert the following day as did the patients who received placebo. Useful for most adult insomniacs. Restoril (temazepam) has been used effectively in adult and elderly patient's with recurring insomnia, and in situations requiring restful sleep. New restoril (temazepam) one dose… one night's sleep. No more… no less. |
| Abstract | temazepam, Sandoz, hour glass in front of sunset on water in bottom left, graph on opposite page. Four different patietns with their arms in the air looking well-rested, black and white image of bed with pill on it, written prescription for restoril. |