| Note |
Metabolites. Just one of its clinical advantages ..a concert of action. Active metabolites for active therapy- throughout therapy. Valium (diazepam/Roche) not only provides diazepam- active itself- but also a unique combination of three major active metabolites: desmethyl-diazepam, 3-hydroxydiazepam and oxazepam. Working together, diazepam and its three metabolites produce the distinctive mind and muscles concert of action you're come to expect form valium,- and valium alone. In addition- the metabolites of valium present another advantage. Because of the overlapping half-lives of its metabolites, valium, unlike short-acting agents with inactive metabolites, provides a tapering effect, which compliments gradual reduction of dosage and smooths transition to independent coping. Builds to steady-state predictability without accumulating beyond. With valium, steady-state levels are readily and predictably achieved, typically within 5-7 days, without accumulating beyond. And once the steady state level is reached, sudden symptom breakthrough is unlikely even if occasional doses are forgotten or skipped. Points to consider about duration of therapy… patients should understand that valium will be prescribed only as long as needed to achieve the therapeutic goals you've established. Periodic assessment of the need for psychoactive medication is recommended…. And about discontinuation of therapy. While tapering the dosage of valium is rarely necessary after short term therapy on recommended dosages, gradual discontinuation of medication is good medical practice in patients who have received higher doses for extended periods. When this is done, untoward side effects are unlikely. Throughout therapy, in fact, side effects are rare with valium and are seldome more serious than drowsiness, fatigue, and ataxia. In the management of clinical anxiety and psychic tension: Valium diazepam/ Roche. Smooth transition to independent coping. |
