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1971 JNMA Nobrium

1971 JNMA Nobrium

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Metadata (MODS)
Titles	1971 JNMA Nobrium
Related Item
Genre	medicine
Identifier	JNMA015
Note	NOBRIUM: TOWARDS TRUE PRECISION IN THE CONTROL OF EXCESSIVE ANXIETY. The amygdala in the limbic plays the crucial part in the generation and transmission of anxiety. In excessive anxiety the hypothalamus constantly prepares the body for a violent physical challenge which never materializes, producing a long list of anxiety symptoms and psychosomatic disorders. When sensory stimuli reverberate through the cortex it evaluates those stimuli and decides, in a flat, uninflected way, the response to make. In 1937, it was suggested that the limbic system was the anatomical source of the emotions which intensified the individual's response. Later research work suggested the amygdala as the source of aggression and anxiety. This was confirmed by the experiments in which removal of the amygdala produced a tranquilizing or taming effect on previously wild animals and others where electrical simulation produced a whole spectrum of emotions from anxiety, through panic to extreme rage. Close to the amygdala-and with many connections to it-is the hypothalamus, the structure which acts, through the autonomic nervous system, the neuro-endocrine structure and the neuro-secretory mechanisms to produce an appropriate level of physical arousal. This physical arousal can be produced in circumstances where it can serve no useful purpose, during academic examinations, for example and even when watching anxiety-provoking films. If such changes are too frequent or too prolonged they may permanently damage the heart or circulation. The physical changes produced by anxiety are many; the electrical resistance of the skin changes, so does muscle tone, secretion of saliva, respiration and respiratory efficiency. A specific study on soldiers subjected to experimental stress recounted changes in the blood picture and concluded that such changes could '…trigger or otherwise promote psychosomatic and psychiatric disease'. Nobrium acts mainly on the amygdala and has a smaller, complementary action on the hypothalamus, curbing both the emotional and physical manifestation of anxiety. In over 50 clinical trials, involving more than 5,000 patients, Nobrium relieved more than 80% of the individual symptoms detailed in the trial reports. It has been shown that Nobrium exerts its major effect on the amygdala and has a smaller, complementary, action on the hypothalamus. This suggests that Nobrium should control both emotional and physical symptoms of anxiety without interfering with other functions. Nobrium: Good to excellent response in over 80% of the anxiety symptoms and associated disorders. In over 50 published reports of clinical trials with Nobrium, involving more than 5,000 patients, details of 3,443 individual symptoms or associated disorders were reported. A good to excellent response was achieved in 2,781 (80.8%) of those symptoms. In no group, other than headache, did the good to excellent response drop below 73%. Nobrium: Thirteen double-blind trials. Thirteen of the published clinical trials were double-blind studies comparing Nobrium with either placebo, phenothiazine, barbiturate or chlordiazepoxide. In every case Nobrium was clearly better than the placebo and this was frequently confirmed by statistical analysis. In a trial against a phenothiazine Nobrium produces 64% good to very good responses, double that produced by the other treatment. Against phenobarbitone Nobrium produced a 76% good to very excellent response of 29% to the phenobabitone. Compared with chlordiazepoxide, both were effective but Nobrium seemed to have a better effect in somatic anxiety, as opposed to the 'free floating' variety. Nobrium and motor performance. In one double-blind study Nobrium was compared with a placebo with regard to its interaction with alcohol. The conclusion was that Nobrium '…in general, did not affect human mental or motor performance either alone or in combination with alcohol'. (Despite the findings of this trial patients should be instructed to avoid alcohol while under treatment with Nobrium). A study in which 75 trolley bus drivers were treated while they went on working as usual tends to confirm this. No significant difference could be found in alertness between subjects treated with Nobrium and those given a placebo. Nobrium and anxiety in the body. Particular attention was paid in a number of reporrs to patients suffering from specific physical symptoms and disorders in association with anxiety. Details of 563 such cases could be extracted from the literature. Of the group 406 (72.1%) showed a good to excellent response to treatment.
Abstract	Medazepam, Roche ***Also says "distributed in Nigeria by Kingsway Chemists", Page 2: Featureless silhouette of a head with the brain in it, labeled with corresponding parts. Also a horizontal, featureless, cartoon silhouette of the body labeled for somatic and psychosomatic disorders continuing onto pg 3. Page 4/5 smaller versions. Smaller versions of the earlier silhouette image shaded in to depict the level of efficacy during drug trial. Four page ad.