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1971 JNMA Sinequan

1971 JNMA Sinequan

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Metadata (MODS)
Titles 1971 JNMA Sinequan
Related Item
Genre medicine
Identifier JNMA006
Note Unsurpassed by leading fixed combinations, leading antidepressants & leading tranquilizers. New Sinequan doxepin HCl the first single agent with potent antianxiety and antidepressant actions. Effective in treatment of coexisting anxiety/depression or prominent anxiety or prominent depression. Successful in co-existing anxiety/depression. Krakowskit reported "It was observed repeatedly that the most common target symptoms showing improvement in the doxepin group were anxiety, depression, somatization and hypochondriasis, in that order. Such a clear sequence was not observed in the amitriptyline-perphenazine group." Krakowski reported: "Doxepin is a useful drug in the treatment of depression and its biphasic quality constitutes a very positive property in those depressions, which show presence of concomitant anxiety or hyperexcitation." Results of double-blind studies Sinequan (Doxepin HCl) vs. perphenazine-amitriptyline Sinequan was compared to a fixed combination (perphenazine-amitriptyline) in three double-blind studies of 79 patients showing symptoms of anxiety and depression. Sinequan was found to be at least as effective as - and in most cases, more effective than- the combination. Sinequan successful when anxiety is predominant. Johnstone and Claghorn reported: "The most striking improvement (with Sinequan) occurs in sleeping disturbances and in somatic concomitants of anxiety, fidgeting, irritability, tenseness, inability to relax, muscular stiffness, feelings of weakness, tachycardia, palpitation, giddiness, shortness of breath, dyspepsia, bowel disturbances. Dunlop reported: "This drug (Sinequan) has a dual or biphasic action. It is of benefit at lower doses in the management of anxiety, whether it exists as a separate entity, ot associated with varying degrees of depression." Sinequan was compared with chlordiazepoxide in 101 patients. Sinequan was compared with diazepam in 182 patients. "The onset of therapeutic effect with Sinequan was prompt and in all instances was manifest within the first week." (Mean 2.5 days). "…a prime candidate in the choice of a drug to be employed routinely in the management of Psychoneurotic anxiety…" Unlike the benzodiazepine tranquilizers, Sinequan is non-euphoriant and dependence has not been reported to date. Sinequan may be discontinued or the dose reduced without nausea, chills, or fever. Drug induced depression is extremely rare as are ataxia, changes in libido and paradoxic behavioral effects. Unlike the tricyclic antidepressants, Sinequan has no interaction with adrenergic blockers for hypertension and less effect on the cardiovascular system. Drug related EKG abnormalities have not been reported. Insomnia and other sleep disturbances seldom occur. Unlike the phenothiazines, Sinequan has not caused jaundice, hypotension, blood dyscrasias, or retinal and pigment changes. Extra pyramidal effects are rare and have occurred only at higher dose levels.
Abstract Doxepin HCl, Pfizer Pharmaceutical Division, A Venn diagram type images: left side has a red circle titled anxiety, right circle is blue and titled depression, with the overlapping being black. Also many charts showing study results and side effects/doses. 4 page ad. Side effects. dosages are in chart form. **Before this ad, this is an advertisement for Guinness Beer** Also lots of study results and numbers in chart form.