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1977 British Journal of Psychiatry Anafril
1977 British Journal of Psychiatry Anafril
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Metadata (MODS) |
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| Titles | 1977 British Journal of Psychiatry Anafril |
| Related Item | |
| Genre | medicine |
| Genre | medicines (psychiatric) |
| Identifier | BJP1977Jan_Mar20 |
| Note | Anafranil is the most recent addition to the Geigy range of psychotropic drugs. In addition to its use in depression, where it has proved to be effective both by the oral route and by intravenous infusion (in the more seriously depressed patient), Anafranil is becoming established as a leading drug treatment for obsessional and phobic disorders. We will be pleased to forward further information relating to the use of Anafranil in the treatment of depression and phobic and obsesisonal disorders on request. Anafranil in depression. "The most striking finding however, was the number of patients who showed spectacular improvement and who had been ill for considerable periods of time. By and large this group were of a chronic grumbling type who sought much and constant medical attention and yet did not reward the doctor by getting better." "The different between the proportion of patients in hospital who improved when treated with electroconvulsive therapy, conventional antidepressant drug therapy and intravenous infusion of clomipramine was statistically significant in favour of the last mentioned treatment. Patients on clomipramine as a group needed fewer treatments and reutrned to work more rapidly than did their counterparts having electroconvulsive therapy." "72% (of 57 patients) showed a very good or good response and 96% made some improvement. This compares favourably with the response of similar groups of severely depressed patients to E.C.T. and it is postulated that intravenous chlorimipramine can be offered as an alternative form of treatment." "Oral group: 78 per cent showed a very good or good response and 96 per cent improved to some extent. This also compared favourably with the results obtained with other antidepressant drugs in similar groups of patients."Anafranil in obsessional/phobic disorders. "Clomipramine has the two distinct properties of being an anti-depressive and an anti-obsessional drug." "Obsessional illnesses have always been notorious for their resistance to treatment and phobic states, especially when they are diffuse and polysymptomatic, do not respond always to deconditioning or flooding techniques…A treatment which offers brevity with a 70% chance of disappearance or considerable reduction in symptoms is worth offering to patients as a first choice of therapies." "It is our view that clomipramine not only gives good results in severe and moderate depressive states, but it is emerging as the treatment of choice in obsessive compulsive disorders and phobic states." "The mode of action of Anafranil is unknown but without doubt it appears to exert a beneficial effect on neurotic responses in general and phobic and obsessional states in particular." |
| Abstract | Clomipramine, Geigy, text only- Ad contains a bunch of quotes from studies. |