| Note |
New for your depressed patients Prothiaden tablets 75mg. 24 hours benefit from a bedtime dose. Because dothiepin is inherently long-acting, a single bedtime dose of Prothiaden Tablets 75mg provides relief of symptoms throughout the day and night. Calculations based on a half-life of approximately 50 houts indicated that following one 75mg dose the range of plasma concentrations over 24 hours should be small compared to the average steady state concentration. A more effective, better tolerated treatment. A bedtime dose of Prothiaden 75mg was compared with 25mg amitriptyline three times daily. "The results showed that dothiepin caused a greater improvement than amitriptyline after 4 weeks of treatment as judged by depression scores, total scores and global assessments." Side effects minimised. "In the amitriptyline group one out of 16 patients did not report side effects at any time during the trail. In the dothiepin group, 10 out of 14 patients did not report side effects." Improves sleep patterns. After four weeks of Prothiaden 75mg treatment, insomnia improved by 78%. "These results suggest that the use of a single dose at night is useful in helping insomnia in depressed patients. Relieve associated anxiety. A bedtime dose of Prothiaden 75mg has been shown to reduce mean anxiety scores. |
