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| Titles |
1977 British Journal of Psychiatry Merital |
| Related Item |
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| Genre |
medicine |
| Genre |
medicines (psychiatric) |
| Identifier |
BJP1977oct-dec10 |
| Note |
New Merital 25. Two distinct actions in depression. 1. Improves depressed mood. It is widely believed that the ability of antidepressants to affect central amine neurotransmitters may be the basis for their therapeutic activity. Merital 25 is a potent inhibitor of noradrenaline re-uptake from central synapses, an effect which has been related to improvement of mood in depression. 2. Restores drive. Merital 25 is the first effective psychotropic agent for depression which has a significant inhibitory effect on dopamine re-uptake from central synapses, an action which is believed to enhance the general level of drive and activity. An entriely new type of agent for depression. Free from sedative effect. Of 938 patients treated with Merital 25, dorwsiness was noted in only six (0.64%). Exceptionally well tolerated. Anticholinergic side effects were seen in less than 2% of patients treated with Merital 25. Rapid onset of action. Studies have shown that patients treated with Merital 25 respond within 7 to 10 days. Freedom from cardiotoxic and hypotensive effects. No signs of cardiotoxicity or changes in ECG in patients have been reported. |
| Abstract |
Nomifensine, Hoechst, An image of 2 brains; in one of them there are blue cylinder objects sticking out. In the second brain, there are red rectangular objects sticking out. |
